A novel therapeutic approach in tetanus: Botulinum toxin

Botulinum toxin A for trismus in cephalic tetanus.

Cephalic tetanus is a localized form of tetanus. As in generalized forms, trismus is a prominent feature of the disease, leading to considerable difficulty in feeding, swallowing of the saliva and mouth hygiene. These difficulties often precede respiratory problems and aspiration bronchopneumonia is a frequent life-threatening complication. Muscle relaxants other than curare drugs may show a li...

Therapeutic Uses of Botulinum Toxin

The most poisonous substance known to man, botulinum toxin has successfully established itself as a therapeutic agent over the years. Initially used to treat strabismus, botulinum toxin is now an accepted treatment in a wide spectrum of disorders and has over a 100 potential medical applications. The somewhat loosely-applied term 'wonder drug' could not be better employed to describe the remedi...

Therapeutic ptosis with botulinum toxin in epikeratoplasty.

Therapeutic Use of Botulinum Toxin in Neurorehabilitation

The botulinum toxins (BTX), type A and type B by blocking vesicle acetylcholine release at neuro-muscular and neuro-secretory junctions can result efficacious therapeutic agents for the treatment of numerous disorders in patients requiring neuro-rehabilitative intervention. Its use for the reduction of focal spasticity following stroke, brain injury, and cerebral palsy is provided. Although the...

Botulinum Neurotoxins and Botulism: A Novel Therapeutic Approach

Specific treatment is not available for human botulism. Current remedial mainstay is the passive administration of polyclonal antibody to botulinum neurotoxin (BoNT) derived from heterologous species (immunized animal or mouse hybridoma) together with supportive and symptomatic management. The antibody works extracellularly, probably by blocking the binding of receptor binding (R) domain to the...